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Humanity's farthest and longest-lived spacecraft, Voyager 1 and 2, achieve 40 years of operation and exploration this August and September. Despite their vast distance, they continue to communicate with NASA daily, still probing the final frontier. Their story has not only impacted generations of current and future scientists and engineers, but also Earth's culture, including film, art, and music. Each spacecraft carries a Golden Record of Earth sounds, pictures, and messages. Since the spacecraft could last billions of years, these circular time capsules could one day be the only traces of human civilization.

"None of us knew, when we launched 40 years ago, that anything would still be working, and continuing on this pioneering journey," said Ed Stone, Voyager project scientist at Caltech in Pasadena, California. "The most exciting thing they find in the next five years is likely to be something that we didn't know was out there to be discovered."

Tropical Storm Nalgae can’t seem to get a break from vertical wind shear. The storm has been dealing with wind shear since it formed and NASA’s Terra satellite observed that was still the case on August 4.

A new technique for evaluating drug safety can detect stress on cells at earlier stages than conventional methods, which mostly rely on detecting cell death. The new method uses a fluorescent sensor that is turned on in a cell when misfolded proteins begin to aggregate -- an early sign of cellular stress. The method can be adapted to detect protein aggregates caused by other toxins as well as diseases such as Alzheimer’s or Parkinson’s. A paper describing the new method, by a team of researchers at Penn State University, appears in the journal Angewandte Chemie International Edition.

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K pathway is common to many cancers, K-80003 could have broad therapeutic applications. Tarrex Biopharma, Inc. has licensed the compound and announced they will soon begin Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer.

Chemists have figured out a new, more efficient way to create carbon-based fuels from carbon dioxide (CO2). In chemical reactions performed in the lab, a Caltech team has identified a new additive that helps selectively convert CO2 into fuels containing multiple carbon atoms—a step toward ultimately making renewable liquid fuels that are not derived from coal or oil.

"The results were quite shocking," says Jonas Peters, Bren Professor of Chemistry at Caltech and director of the Resnick Sustainability Institute, who jointly led the research in collaboration with Theodor Agapie, professor of chemistry at Caltech. "Usually, in these types of reactions with CO2, you see a lot of by-products like methane and hydrogen. In this case, the reaction was highly selective for the more desirable fuels that contain multiple carbons—such as ethylene, ethanol, and propanol. We saw an 80 percent conversion to these multi-carbon fuel products, with only 20 percent or so going into hydrogen and methane."