The Yale laboratory of Sidi Chen, assistant professor of genetics in the Systems Biology Institute and Yale Cancer Center, has developed advanced gene-editing and screening technology to find new targets for cancer immunotherapy.
The Yale laboratory of Sidi Chen, assistant professor of genetics in the Systems Biology Institute and Yale Cancer Center, has developed advanced gene-editing and screening technology to find new targets for cancer immunotherapy.
In a new study published Sept. 23 in Nature Biotechnology, Chen and colleagues report that using T cells containing modifications of those gene targets reduced tumors in a mouse model of glioblastoma, a brain cancer that is especially difficult to treat.
The brain has a very limited immune system activity and therefore is not a particularly promising organ for immunotherapy, note the researchers. Chen’s lab developed a sophisticated viral vector with an embedded transposon, or jumping gene, that facilitates the genetic screening capabilities of T cells.
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Image: Multi-colored markers of the immune system are captured in glioblastoma tumors. CREDIT: Yale University
