A new study has shown that following brain ischemia caused by cerebral blockage in mice both immediate and delayed reduction in body temperature helped limit cell death and levels of a protein called dynamin. These results, which suggest that dynamin may have a role in—and be a potential drug target for—stroke-related neuronal cell death, are reported in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal website until September 16, 2017.
A new study has shown that following brain ischemia caused by cerebral blockage in mice both immediate and delayed reduction in body temperature helped limit cell death and levels of a protein called dynamin. These results, which suggest that dynamin may have a role in—and be a potential drug target for—stroke-related neuronal cell death, are reported in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal website until September 16, 2017.
The article entitled “Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke” is coauthored by Jong Youl Kim, PhD, Nuri Kim, Jong Eun Lee, PhD, and Midori Yenari, MD, University of California, San Francisco and Yonsei University College of Medicine, Seoul, Republic of Korea.
The researchers demonstrated increased expression of dynamin and the cell surface receptor FAS in a mouse model of stroke. They assessed the effects of two cooling approaches on the survival of brain cells: cooling as soon as cerebral blockage occurs (early hypothermia) and cooling that began 1 hour later (delayed hypothermia). The results were compared to those in mice not subjected to hypothermia.
Read more at Mary Ann Liebert, Inc./Genetic Engineering News
Image: Therapeutic Hypothermia and Temperature Management is the only peer-reviewed journal providing clinical advances, best practices, and protocols on this critical, life-saving technology, including its application in cardiac arrest, spinal cord and traumatic brain injury, stroke, and burns. (Credit: Mary Ann Liebert, Inc., publishers)
