Small, deep-water Alaska sponge has molecules that selectively target and kill pancreatic tumor cells

Compared to its dazzling deep-sea coral neighbors, the green Latrunculia austini sponge is pretty drab. Dotted with craters and pitted by deep holes the golf-ball sized sponge is curious-looking rather than beautiful. But green Latrunculia’s unique chemical composition holds a promise much greater than mere beauty.

It was discovered at the bottom of Alaska’s frigid North Pacific Ocean during a NOAA Fisheries research mission in 2005. The mission was straightforward: study bottom-dwelling sea life and habitats supporting Alaska’s $1.8 billion fishing industry. However, in the years since, the small sponge has attracted the attention of multidisciplinary scientists from around the globe. In lab tests, several of Latrunculia austini’s molecules selectively target and kill pancreatic tumor cells, according to biomedical researchers at the Hollings Cancer Center at the Medical University of South Carolina and at the Henry Ford Cancer Institute in Detroit.

“You’d never look at this sponge and think this is a miracle sponge, but it could be,” said Bob Stone, a researcher at NOAA Fisheries’ Alaska Fisheries Science Center. He was the first to discover the sponge in Alaska while operating from a submersible on the North Pacific’s seafloor. His work soon had further reach because of a special collaboration.

By the time Stone found the sponge, his groundbreaking research in Alaska had already intrigued leading biomedical researcher Mark Hamann, the Charles and Carol Cooper SmartState Endowed Chair at the Medical University of South Carolina. Hamann has studied marine life to develop drug leads for more than 20 years. While Hamann explores the ocean in search of rare natural compounds, he also constantly monitors publications for other scientists’ discoveries, which led him to Stone.

Continue reading at NOAA.

Photo via NOAA.