In cooperation with colleagues of the University of Rostock, the University of Luxembourg, the Max Delbrueck Center for Molecular Medicine, the Karlsruhe Institute of Technology and the University of Eastern Finland, the Munich Scientists have now published the results in the journal PLOS ONE. In 2015 they already showed that exposure to particle emissions from heavy fuel oil (HFO) and diesel fuel (DF) adversely affects human lung cells and is responsible for strong biological responses of the cells ("How Ship Emissions Adversely Affect Lung Cells"). For example, inflammatory processes are triggered that may influence the development of interstitial lung diseases. Now the team led by Professor Ralf Zimmermann has found in further studies that macrophages are also influenced by the exhaust gases. These are much more sensitive than lung epithelial cells and therefore react more strongly to exposure. Zimmermann is speaker of the international consortium Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health (HICE), head of the cooperation group Comprehensive Molecular Analytics (CMA) at Helmholtz Zentrum Muenchen and head of the Department of Analytical Chemistry at the University of Rostock.
In cooperation with colleagues of the University of Rostock, the University of Luxembourg, the Max Delbrueck Center for Molecular Medicine, the Karlsruhe Institute of Technology and the University of Eastern Finland, the Munich Scientists have now published the results in the journal PLOS ONE. In 2015 they already showed that exposure to particle emissions from heavy fuel oil (HFO) and diesel fuel (DF) adversely affects human lung cells and is responsible for strong biological responses of the cells ("How Ship Emissions Adversely Affect Lung Cells"). For example, inflammatory processes are triggered that may influence the development of interstitial lung diseases. Now the team led by Professor Ralf Zimmermann has found in further studies that macrophages are also influenced by the exhaust gases. These are much more sensitive than lung epithelial cells and therefore react more strongly to exposure. Zimmermann is speaker of the international consortium Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health (HICE), head of the cooperation group Comprehensive Molecular Analytics (CMA) at Helmholtz Zentrum Muenchen and head of the Department of Analytical Chemistry at the University of Rostock.
"Macrophages are known as scavenger cells of the immune system and respond more sensitively to particulate matter in the lungs than lung epithelial cells, since they are the 'first line of response' against foreign invaders in the lungs such as germs or even fine dust particles," said Sean Sapcariu, first author of the study and doctoral student at the University of Luxembourg, a cooperation partner in HICE. "We found that the ship emissions of heavy fuel oil and diesel fuel had different effects on triggering pro-inflammatory reactions,"said Sapcariu. Fine particles from heavy fuel oil emissions have a stronger effect on the development of pro-inflammatory reactions than particles emitted from diesel ship engines, but the latter more strongly influence other fundamental biological processes such as DNA-, RNA- and protein-synthesis.
Read more: EurekAlert!
Image: Air pollution caused by ships via NOAA
