Wayne State University researchers are reporting new findings that demonstrate a link between exposure to per- and polyfluorinated alkyl substances (PFAS) in males and health issues in their offspring.
Wayne State University researchers are reporting new findings that demonstrate a link between exposure to per- and polyfluorinated alkyl substances (PFAS) in males and health issues in their offspring.
The study, “Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome,” published recently in Environment International, assessed the effect of PFAS mixtures on the sperm methylome and transcriptional changes in offspring metabolic tissues such as in the liver and fat.
“PFAS research is important, especially in Michigan,” said Michael C. Petriello, Ph.D., assistant professor in the Institute of Environmental Health Sciences and the Department of Pharmacology. “It has been recently in the news, since the EPA is finally starting to regulate PFAS chemicals and include them as part of the Clean Water Act. All over the country, communities will have standards they will have to meet. PFAS are associated with many chronic diseases and can impact inflammation and the immune system, for instance. This work is focused on reproductive outcomes, fertility and offspring metabolism. The idea that exposure of the father could affect the health of offspring is entirely new.”
Read more at Wayne State University
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