Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth. Because the PI3K pathway is common to many cancers, K-80003 could have broad therapeutic applications. Tarrex Biopharma, Inc. has licensed the compound and announced they will soon begin Phase 1 clinical trials at the Dana Farber Cancer Center for patients with colorectal cancer.

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Seasonal and diurnal rhythms determine the life cycle of many animal species. In equids this is not only true for wild species such as the Przewalski but season-dependent metabolic changes also exist in domesticated horses. Horses can reduce their metabolic activity during the cold season and thus reduce heat loss. The effects of such seasonal changes on pregnancy and foetal development, however, have not been investigated so far. Researchers from Vetmeduni Vienna could now demonstrate that foals born in winter are smaller than herd mates born later in the year.

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