LA JOLLA—Normally when we think of viruses, from the common cold to HIV, we want to boost people’s immunity to fight them. But for scientists who develop therapeutic viruses (to, for example, target cancer cells or correct gene deficiencies) a more important question is: How do we keep people’s natural immune responses at bay? In these cases, an overenthusiastic immune response actually undermines the therapy.

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LA JOLLA—Just as an invasive weed might need nutrient-rich soil and water to grow, many cancers rely on the right surroundings in the body to thrive. A tumor’s microenvironment—the nearby tissues, immune cells, blood vessels and extracellular matrix—has long been known to play a role in the tumor’s growth.

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Pioneering new research has provided a fascinating new insight in the quest to determine whether temperature or water availability is the most influential factor in determining the success of global, land-based carbon sinks.

The research, carried out by an international team of climate scientists including Professors Pierre Friedlingstein and Stephen Sitch from the University of Exeter, has revealed new clues on how land carbon sinks are regulated on both local and global scales.

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One of Alaska’s most abundant freshwater fish species is altering its breeding patterns in response to climate change. This could impact the ecology of northern lakes, which already acutely feel the effects of a changing climate.

That’s the main finding of a recent University of Washington study published in Global Change Biology that analyzed reproductive patterns of three-spine stickleback fish over half a century in Alaska’s Bristol Bay region. The data show that stickleback breed earlier and more often each season in response to earlier spring ice breakup and longer ice-free summers.

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Sediment found at the site of one of the largest lakes in Earth’s history could provide a fascinating new insight into how inland regions responded to global climate change millions of years ago.

A pioneering new study, carried out by a team of British-based researchers, has analysed sediments from the site of the vast lake which formed in the Sichuan Basin, in China, around 183 million years ago in the Jurassic period.

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For decades, scientists have theorized that the movement of Earth’s tectonic plates is driven largely by negative buoyancy created as they cool. New research, however, shows plate dynamics are driven significantly by the additional force of heat drawn from the Earth’s core.

The new findings also challenge the theory that underwater mountain ranges known as mid-ocean ridges are passive boundaries between moving plates. The findings show the East Pacific Rise, the Earth’s dominant mid-ocean ridge, is dynamic as heat is transferred.

David B. Rowley, professor of geophysical sciences at the University of Chicago, and fellow researchers came to the conclusions by combining observations of the East Pacific Rise with insights from modeling of the mantle flow there. The findings were published Dec. 23 in Science Advances.

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