Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, which chronically infects around half of all humans. However, unlike tumour viruses, bacteria do not deposit transforming genes in their host cells and how they are able to cause cancer has so far remained a mystery. An interdisciplinary research team at the Max Planck Institute in Berlin in collaboration with researchers in Stanford, California, has now discovered that the bacterium sends stem cell renewal in the stomach into overdrive – and stem cell turnover has been suspected by many scientists to play a role in the development of cancer. By showing that the stomach contains two different stem cell types, which respond differently to the same driver signal, they have uncovered a new mechanism of tissue plasticity. It allows tuning tissue renewal in response to bacterial infection.
articles
Smoking Raises Risk of Aneurysm Recurrence After Endovascular Treatment
In a new study, researchers report people who have experienced an aneurysm have another reason to quit smoking.
Investigating the Enigma of Clouds and Climate Change
Clouds perform an important function in cooling the planet as they reflect solar energy back into space. Yet clouds also intensify warming by trapping the planet’s heat and radiating it back to earth. As fossil fuel emissions continue to warm the planet, how will this dual role played by clouds change, and will clouds ultimately exacerbate or moderate global warming?
Simulation shows the high cost of dementia, especially for families
A new simulation of how the costs and the course of the dementia epidemic affect U.S. families finds that neurodegenerative conditions can more than double the health care expenditures of aging and that the vast majority of that financial burden remains with families rather than government insurance programs.
NASA Protects Its Super Heroes From Space Weather
It’s not a bird or a plane but it might be a solar storm. We like to think of astronauts as our super heroes, but the reality is astronauts are not built like Superman who gains strength from the sun. In fact, much of the energy radiating from the sun is harmful to us mere mortals.
NASA's Rocket to Nowhere Finally Has a Destination
On a Thursday afternoon in June, a 17-foot-tall rocket motor—looking like something a dedicated amateur might fire off—stood fire-side-up on the salty desert of Promontory, Utah. Over the loudspeakers, an announcer counted down. And with the command to fire, quad cones of flame flew from the four inverted nozzles and grew toward the sky. As the smoke rose, it cast a four-leaf clover of shadow across the ground.