A McGill-led multi-institutional research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks – the excitatory and inhibitory networks.
A McGill-led multi-institutional research team has discovered that during memory consolidation, there are at least two distinct processes taking place in two different brain networks – the excitatory and inhibitory networks. The excitatory neurons are involved in creating a memory trace, and the inhibitory neurons block out background noise and allow long-term learning to take place.
The team, led by McGill University Professors Nahum Sonenberg and Arkady Khoutorsky, Université de Montréal Professor Jean-Claude Lacaille, and University of Haifa Professor Kobi Rosenblum, senior authors on the paper published today in Nature, also found that each neuronal system can be selectively manipulated to control long-term memory. The research, which answers a long-standing question about which neuronal subtypes are involved in memory consolidation, has potential implications for novel targets for medication for disorders such as Alzheimer’s disease and autism, which involve altered memory processes.
How do short-term memories (which last just a few hours) transform into long-term memories (which may last years)? It’s been known for decades that this process, called memory consolidation, requires the synthesis of new proteins in brain cells. But until now, it hasn’t been known which subtypes of neurons were involved in the process.
Read more at: McGill University
