The two-dose Ebola vaccine regimen, Zabdeno® (Ad26.ZEBOV) and Mvabea® (MVA-BN-Filo), has been developed by the Janssen Pharmaceutical Companies of Johnson & Johnson for the prevention of Ebola Virus Disease caused by the Zaire Ebola virus species.
The two-dose Ebola vaccine regimen, Zabdeno® (Ad26.ZEBOV) and Mvabea® (MVA-BN-Filo), has been developed by the Janssen Pharmaceutical Companies of Johnson & Johnson for the prevention of Ebola Virus Disease caused by the Zaire Ebola virus species. The vaccine regimen leveraged Janssen’s AdVac® vaccine technology, plus Bavarian Nordic’s established MVA-BN® technology. It is specifically designed to induce long-term immunity against the Ebola virus in adults and children aged one year and above. As such, it can be used to support preventive vaccination in countries most at risk of outbreaks.
The University of Oxford played an important role in supporting the development of this vaccine. In response to the West Africa Ebola crisis, we collaborated in a unique, multi-partner global effort to accelerate the vaccine through multiple clinical trials across three continents.
'In 2014 the team at the Oxford Vaccine Group asked for volunteers to take part in a ‘first in human’ study of a new vaccine schedule against Ebola virus disease, which at that time was causing a devastating outbreak in West Africa,' says Professor Matthew Snape, the Chief Investigator on the Ebola vaccine project. 'The response from the public was overwhelming, and within a few months we knew enough about the vaccine and its safety to allow progression to studies enrolling many thousands of participants in sub-Saharan Africa.
Read more at: University of Oxford
